Synthesis, Characterization and in Vitro Antitumor Activity of Platinum(II) Oxalato Complexes Involving 7-Azaindole Derivatives as Coligands

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33152618" target="_blank" >RIV/61989592:15310/14:33152618 - isvavai.cz</a>
Result on the web
<a href="http://www.mdpi.com/1420-3049/19/8/10832/htm" target="_blank" >http://www.mdpi.com/1420-3049/19/8/10832/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules190810832" target="_blank" >10.3390/molecules190810832</a>

Result language
angličtina
Original language name
Synthesis, Characterization and in Vitro Antitumor Activity of Platinum(II) Oxalato Complexes Involving 7-Azaindole Derivatives as Coligands
Original language description
The platinum(II) oxalato complexes [Pt(ox)(naza)(2)] (1-3) were synthesized and characterized by elemental analysis (C, H, N), multinuclear NMR spectroscopy (H-1, C-13, N-15, Pt-195) and electrospray ionization mass spectrometry (ESI-MS); naza = 4-chloro-7-azaindole (4Claza; 1), 3-bromo-7-azaindole (3Braza; 2) or 4-bromo-7-azaindole (4Braza; 3). The prepared substances were screened for their in vitro antitumor activity on the osteosarcoma (HOS) and breast adenocarcinoma (MCF7) human cancer cell lines,where 2 showed moderate antitumor effect (IC50 = 27.5 uM, and 18.3 uM, respectively). The complex 2 was further tested on a panel of six others human cancer cell lines, including the malignant melanoma (G361), cervix carcinoma (HeLa), ovarian carcinoma (A2780), cisplatin-resistant ovarian carcinoma (A2780R), lung carcinoma (A549) and prostate adenocarcinoma (LNCaP). This substance was found to be moderate antitumor effective against G361 (IC50 = 17.3 uM), HeLa (IC50 = 31.8 uM) and A2780
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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