In Vitro Cytotoxic-Active Platinum(II) Complexes Derived from Carboplatin and Involving Purine Derivatives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F10%3A10213214" target="_blank" >RIV/61989592:15310/10:10213214 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
In Vitro Cytotoxic-Active Platinum(II) Complexes Derived from Carboplatin and Involving Purine Derivatives
Original language description
Six platinum(II) complexes of the general formula [Pt(cbdc)-(HLn)(2)] (1-6; cbdc = cyclobutane-1,1-dicarboxylate and HL1-HL6 = benzyl-substituted 6-benzylamino-2-chloro-9-iso-propylpurine derivatives) have been synthesized. The prepared complexes were characterized by elemental analysis and FTIR, Raman and NMR spectroscopy. The complexes 1-6 were tested for their in vitro cytotoxicity against K-562 (chronic myelogenous leukaemia) and MCF7 (breast adenocarcinoma) human cancer cell lines. Values of IC50 ranged from 4.5 to 14.1 mu m for the K-562 cells and from 4.3 to 21.0 mu m for the MCF7 cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
ISSN
1434-1948
e-ISSN
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Volume of the periodical
2010
Issue of the periodical within the volume
22
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
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UT code for WoS article
000281061700006
EID of the result in the Scopus database
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