Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00534516" target="_blank" >RIV/61388955:_____/20:00534516 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21340/20:00354326

Result on the web

<a href="http://hdl.handle.net/11104/0312700" target="_blank" >http://hdl.handle.net/11104/0312700</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsnano.9b04898" target="_blank" >10.1021/acsnano.9b04898</a>

Result language

angličtina

Original language name

Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy

Original language description

Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). Previously, nanoencapsulation of radioactive crystals within carbon nano-tubes, followed by end-closing, resulted in the formation of nanocapsules that allowed ultrasensitive imaging in healthy mice. Herein we report on the preparation of nanocapsules initially sealing ´cold´ isotopically enriched samarium (Sm-152), which can then be activated on demand to their ´hot´ radioactive form (Sm-153) by neutron irradiation. The use of ´cold´ isotopes avoids the need for radioactive facilities during the preparation of the nanocapsules, reduces radiation exposure to personnel, prevents the generation of nuclear waste, and evades the time constraints imposed by the decay of radionuclides. A very high specific radioactivity is achieved by neutron irradiation (up to 11.37 GBq/mg), making the ´hot´ nanocapsules useful not only for in vivo imaging but also therapeutically effective against lung cancer metastases after intravenous injection. The high in vivo stability of the radioactive payload, selective toxicity to cancerous tissues, and the elegant preparation method offer a paradigm for application of nanomaterials in radiotherapy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Nano

ISSN

1936-0851

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

129-141

UT code for WoS article

000510531500008

EID of the result in the Scopus database

2-s2.0-85076733884