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Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F20%3A00354326" target="_blank" >RIV/68407700:21340/20:00354326 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388955:_____/20:00534516

  • Result on the web

    <a href="https://doi.org/10.1021/acsnano.9b04898" target="_blank" >https://doi.org/10.1021/acsnano.9b04898</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1021/acsnano.9b04898" target="_blank" >10.1021/acsnano.9b04898</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy

  • Original language description

    Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). Previously, nanoencapsulation of radioactive crystals within carbon nano-tubes, followed by end-closing, resulted in the formation of nanocapsules that allowed ultrasensitive imaging in healthy mice. Herein we report on the preparation of nanocapsules initially sealing "cold" isotopically enriched samarium (Sm-152), which can then be activated on demand to their "hot" radioactive form (Sm-153) by neutron irradiation. The use of "cold" isotopes avoids the need for radioactive facilities during the preparation of the nanocapsules, reduces radiation exposure to personnel, prevents the generation of nuclear waste, and evades the time constraints imposed by the decay of radionuclides. A very high specific radioactivity is achieved by neutron irradiation (up to 11.37 GBq/mg), making the "hot" nanocapsules useful not only for in vivo imaging but also therapeutically effective against lung cancer metastases after intravenous injection. The high in vivo stability of the radioactive payload, selective toxicity to cancerous tissues, and the elegant preparation method offer a paradigm for application of nanomaterials in radiotherapy.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10301 - Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    ACS NANO

  • ISSN

    1936-0851

  • e-ISSN

    1936-086X

  • Volume of the periodical

    14

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    13

  • Pages from-to

    129-141

  • UT code for WoS article

    000510531500008

  • EID of the result in the Scopus database