Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F20%3A00354326" target="_blank" >RIV/68407700:21340/20:00354326 - isvavai.cz</a>
Alternative codes found
RIV/61388955:_____/20:00534516
Result on the web
<a href="https://doi.org/10.1021/acsnano.9b04898" target="_blank" >https://doi.org/10.1021/acsnano.9b04898</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsnano.9b04898" target="_blank" >10.1021/acsnano.9b04898</a>
Alternative languages
Result language
angličtina
Original language name
Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy
Original language description
Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). Previously, nanoencapsulation of radioactive crystals within carbon nano-tubes, followed by end-closing, resulted in the formation of nanocapsules that allowed ultrasensitive imaging in healthy mice. Herein we report on the preparation of nanocapsules initially sealing "cold" isotopically enriched samarium (Sm-152), which can then be activated on demand to their "hot" radioactive form (Sm-153) by neutron irradiation. The use of "cold" isotopes avoids the need for radioactive facilities during the preparation of the nanocapsules, reduces radiation exposure to personnel, prevents the generation of nuclear waste, and evades the time constraints imposed by the decay of radionuclides. A very high specific radioactivity is achieved by neutron irradiation (up to 11.37 GBq/mg), making the "hot" nanocapsules useful not only for in vivo imaging but also therapeutically effective against lung cancer metastases after intravenous injection. The high in vivo stability of the radioactive payload, selective toxicity to cancerous tissues, and the elegant preparation method offer a paradigm for application of nanomaterials in radiotherapy.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10301 - Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS NANO
ISSN
1936-0851
e-ISSN
1936-086X
Volume of the periodical
14
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
129-141
UT code for WoS article
000510531500008
EID of the result in the Scopus database
—