All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Oleate-modified hyaluronan: Controlling the number and distribution of side chains by varying the reaction conditions

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F21%3A00543196" target="_blank" >RIV/61388955:_____/21:00543196 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/21:10431416

  • Result on the web

    <a href="http://hdl.handle.net/11104/0320467" target="_blank" >http://hdl.handle.net/11104/0320467</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.carbpol.2021.118197" target="_blank" >10.1016/j.carbpol.2021.118197</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Oleate-modified hyaluronan: Controlling the number and distribution of side chains by varying the reaction conditions

  • Original language description

    In this work, low molecular weight hyaluronan was chemically modified by oleoyl moieties utilising mixed anhydrides methodology. The activation of oleic acid with benzoyl chloride in organic solvents miscible with water was followed by NMR spectroscopy. The product selectivity correlates with the solvent's Hildebrand solubility parameter. Furthermore, the effect of the solvent for the mixed anhydride formation was elucidated by density functional theory (DFT) and showed that the reactions are faster in acetonitrile or alcohols than in hexane. Furthermore, the solvent demonstrated to control the substituent distribution pattern along HA chain during esterification. An even distribution of substituents was observed in reactions performed in water mixed with ethers. The substituent distribution pattern clearly influenced the aggregation behaviour of amphiphilic HA, controlling the stability of the delivery system, while increasing the encapsulation capacity.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Carbohydrate Polymers

  • ISSN

    0144-8617

  • e-ISSN

    1879-1344

  • Volume of the periodical

    267

  • Issue of the periodical within the volume

    SEP2021

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    118197

  • UT code for WoS article

    000694014300008

  • EID of the result in the Scopus database

    2-s2.0-85107071968