Oleate-modified hyaluronan: Controlling the number and distribution of side chains by varying the reaction conditions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F21%3A00543196" target="_blank" >RIV/61388955:_____/21:00543196 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/21:10431416
Result on the web
<a href="http://hdl.handle.net/11104/0320467" target="_blank" >http://hdl.handle.net/11104/0320467</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2021.118197" target="_blank" >10.1016/j.carbpol.2021.118197</a>
Alternative languages
Result language
angličtina
Original language name
Oleate-modified hyaluronan: Controlling the number and distribution of side chains by varying the reaction conditions
Original language description
In this work, low molecular weight hyaluronan was chemically modified by oleoyl moieties utilising mixed anhydrides methodology. The activation of oleic acid with benzoyl chloride in organic solvents miscible with water was followed by NMR spectroscopy. The product selectivity correlates with the solvent's Hildebrand solubility parameter. Furthermore, the effect of the solvent for the mixed anhydride formation was elucidated by density functional theory (DFT) and showed that the reactions are faster in acetonitrile or alcohols than in hexane. Furthermore, the solvent demonstrated to control the substituent distribution pattern along HA chain during esterification. An even distribution of substituents was observed in reactions performed in water mixed with ethers. The substituent distribution pattern clearly influenced the aggregation behaviour of amphiphilic HA, controlling the stability of the delivery system, while increasing the encapsulation capacity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Carbohydrate Polymers
ISSN
0144-8617
e-ISSN
1879-1344
Volume of the periodical
267
Issue of the periodical within the volume
SEP2021
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
118197
UT code for WoS article
000694014300008
EID of the result in the Scopus database
2-s2.0-85107071968