Structure and dynamics of the hyaluronan oligosaccharides and their solvation shell in water: organic mixed solvents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F23%3A00566677" target="_blank" >RIV/61389013:_____/23:00566677 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10466169 RIV/70883521:28110/23:63564798
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0144861722014114?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0144861722014114?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2022.120506" target="_blank" >10.1016/j.carbpol.2022.120506</a>
Alternative languages
Result language
angličtina
Original language name
Structure and dynamics of the hyaluronan oligosaccharides and their solvation shell in water: organic mixed solvents
Original language description
Hyaluronan (HA) is a natural polysaccharide occurring ubiquitously in the connective tissues of vertebrates widely used in the cosmetic and pharmaceutic industries. In numerous applications HA oligosaccharides are being chemically modified using reactions incompatible with aqueous solutions, often carried out in water:organic mixed solvents. We carry out molecular-dynamics (MD) simulations of HA oligosaccharides in water:1,4-dioxane and water:tert-butanol mixtures of different compositions. HA molecule causes a separation of the solvent components in its surroundings, especially in tert-butanol containing solutions, constituting thus a solvation shell enriched by water. Furthermore, interactions with ions are stronger than in pure water and depend on the solvent composition. Consequently, the dynamics of the HA chain varies with the solvent composition and causes observable conformational changes of the HA oligosaccharide. Composition of mixed solvents thus enables us to modify the interaction of HA with other molecules as well as its reactivity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Carbohydrate Polymers
ISSN
0144-8617
e-ISSN
1879-1344
Volume of the periodical
304
Issue of the periodical within the volume
15 March
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
120506
UT code for WoS article
000924950800001
EID of the result in the Scopus database
2-s2.0-85145655344