Hyaluronan oligosaccharides form double-helical duplexes in water:1,4-dioxane mixed solvent
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F24%3A63575778" target="_blank" >RIV/70883521:28110/24:63575778 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0144861723010974?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0144861723010974?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2023.121632" target="_blank" >10.1016/j.carbpol.2023.121632</a>
Alternative languages
Result language
angličtina
Original language name
Hyaluronan oligosaccharides form double-helical duplexes in water:1,4-dioxane mixed solvent
Original language description
Hyaluronic acid (HA) is a hydrophilic natural polysaccharide consisting of alternating monosaccharide units of glucuronic acid and N-acetyl glucosamine. In aqueous solutions the electrostatic repulsion of the carboxylate groups hampers the formation of supermolecular structures that can be partially stabilized by the addition of salt. Increased permittivity of the mixed water:organic solvents causes better compensation of the negative charge of HA chains by dissolved cations which changes their interactions with other molecules. In this study we simulate interactions of two HA chains in water:1,4-dioxane and water:tert-butanol mixed solvents with varying NaCl concentrations using molecular dynamics (MD). Anti-parallel double-helix-like duplexes are formed in NaCl-containing water:1,4-dioxane mixture and remain stable even when NaCl is removed. Parallel duplexes separate after a short time. In water:tert-butanol analogous duplexes are unstable. Stability of HA duplexes is thus determined by the solvent composition and the ability of its components to separate in the solvation shell of HA molecules, as well as by the mutual orientation of the chains.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Carbohydrate Polymers
ISSN
0144-8617
e-ISSN
1879-1344
Volume of the periodical
326
Issue of the periodical within the volume
Neuveden
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
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UT code for WoS article
001125438100001
EID of the result in the Scopus database
2-s2.0-85177893349