Folding DNA into origami nanostructures enhances resistance to ionizing radiation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F21%3A00543632" target="_blank" >RIV/61388955:_____/21:00543632 - isvavai.cz</a>

Alternative codes found

RIV/61389005:_____/21:00543632 RIV/46747885:24510/21:00009654

Result on the web

<a href="http://hdl.handle.net/11104/0320821" target="_blank" >http://hdl.handle.net/11104/0320821</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d1nr02013g" target="_blank" >10.1039/d1nr02013g</a>

Result language

angličtina

Original language name

Folding DNA into origami nanostructures enhances resistance to ionizing radiation

Original language description

We report experimental results on damage induced by ionizing radiation to DNA origami triangles which are commonly used prototypes for scaffolded DNA origami nanostructures. We demonstrate extreme stability of DNA origami upon irradiation, which is caused by (i) the multi-row design holding the shape of the origami even after severe damage to the scaffold DNA and (ii) the reduction of damage to the scaffold DNA due to the protective effect of the folded structure. With respect to damage induced by ionizing radiation, the protective effect of the structure is superior to that of a naturally paired DNA double helix. Present results allow estimating the stability of scaffolded DNA origami nanostructures in applications such as nanotechnology, pharmacy or in singulo molecular studies where they are exposed to ionizing radiation from natural and artificial sources. Additionally, possibilities are opened for scaffolded DNA use in the design of radiation-resistant and radio-sensitive materials.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10403 - Physical chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nanoscale

ISSN

2040-3364

e-ISSN

2040-3372

Volume of the periodical

13

Issue of the periodical within the volume

JUN 2021

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

1197-1203

UT code for WoS article

000663025300001

EID of the result in the Scopus database

2-s2.0-85109182478