Selected ion flow tube mass spectrometry for targeted analysis of volatile organic compounds in human breath
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F21%3A00544250" target="_blank" >RIV/61388955:_____/21:00544250 - isvavai.cz</a>
Result on the web
<a href="http://hdl.handle.net/11104/0321281" target="_blank" >http://hdl.handle.net/11104/0321281</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41596-021-00542-0" target="_blank" >10.1038/s41596-021-00542-0</a>
Alternative languages
Result language
angličtina
Original language name
Selected ion flow tube mass spectrometry for targeted analysis of volatile organic compounds in human breath
Original language description
The analysis of volatile organic compounds (VOCs) within breath for noninvasive disease detection and monitoring is an emergent research field that has the potential to reshape current clinical practice. However, adoption of breath testing has been limited by a lack of standardization. This protocol provides a comprehensive workflow for online and offline breath analysis using selected ion flow tube mass spectrometry (SIFT-MS). Following the suggested protocol, 50 human breath samples can be analyzed and interpreted in <3 h. Key advantages of SIFT-MS are exploited, including the acquisition of real-time results and direct compound quantification without need for calibration curves. The protocol includes details of methods developed for targeted analysis of disease-specific VOCs, specifically short-chain fatty acids, aldehydes, phenols, alcohols and alkanes. A procedure to make custom breath collection bags is also described. This standardized protocol for VOC analysis using SIFT-MS is intended to provide a basis for wider application and the use of breath analysis in clinical studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Protocols
ISSN
1754-2189
e-ISSN
1750-2799
Volume of the periodical
16
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
3419-3438
UT code for WoS article
000658129500002
EID of the result in the Scopus database
2-s2.0-85107459131