Voltammetric analysis of mephenoxalone drug in pharmaceutical and biological samples using novel screen-printed sensor with boron-doped diamond electrode
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F23%3A00576141" target="_blank" >RIV/61388955:_____/23:00576141 - isvavai.cz</a>
Alternative codes found
RIV/00216275:25310/23:39920589 RIV/61989592:15310/23:73621797
Result on the web
<a href="https://hdl.handle.net/11104/0345733" target="_blank" >https://hdl.handle.net/11104/0345733</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.snb.2023.134700" target="_blank" >10.1016/j.snb.2023.134700</a>
Alternative languages
Result language
angličtina
Original language name
Voltammetric analysis of mephenoxalone drug in pharmaceutical and biological samples using novel screen-printed sensor with boron-doped diamond electrode
Original language description
A novel screen-printed sensor (SPE) with boron-doped diamond electrode (BDDE) for determination of a muscle relaxant and mild anxiolytic mephenoxalone (MNL) was developed. The sensor utilizes the electrochemical oxidation of MNL, which was firstly studied in aqueous solution using oxygen terminated BDDE. MNL provided an irreversible anodic signal at a potential of + 1380 mV (vs. Ag/AgCl/KCl sat.) over a wide pH range. Britton-Robinson buffer (pH 9) was selected as a suitable electrolyte and the square-wave voltammetric method (SWV) was developed. The low detection limit (55 nmol L–1), wide linear dynamic range (0.1–30 µmol L−1), and good recovery in the analysis of model and pharmaceutical samples (RSD < 1.77%) were attained. Subsequently, the new method was successfully transferred to SPE, which can find application in point-of-care testing. These sensors proved excellent sensitivity and reproducibility in the analysis of biological samples (RSD < 4.94%) without pretreatment and no need of electrolyte. Based on gas chromatography with mass spectrometry (GC-MS) analysis of preparative electrolysis products, a mechanism of the electrochemical oxidation of MNL was proposed, describing the oxidative cleavage of the alkoxybenzene ring. These results were supported with HOMO spatial distribution calculations and atomic charges calculations for arising radical cations, and with spectroelectrochemical measurements.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
<a href="/en/project/GA20-01589S" target="_blank" >GA20-01589S: New strategies for improving sensing properties of novel electrode materials via their surface pretreatment or modification</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sensors and Actuators B - Chemical
ISSN
0925-4005
e-ISSN
0925-4005
Volume of the periodical
397
Issue of the periodical within the volume
DEC 2023
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
134700
UT code for WoS article
001165280100001
EID of the result in the Scopus database
2-s2.0-85173127132