Elevated glutathione in researchers exposed to engineered nanoparticles due to potential adaptation to oxidative stress

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F24%3A00582145" target="_blank" >RIV/61388955:_____/24:00582145 - isvavai.cz</a>
Alternative codes found
RIV/67985858:_____/24:00582145 RIV/68378041:_____/24:00582145 RIV/60162694:G44__/25:00562027 RIV/46747885:24210/24:00012577 and 2 more
Result on the web
<a href="https://www.futuremedicine.com/doi/10.2217/nnm-2023-0207" target="_blank" >https://www.futuremedicine.com/doi/10.2217/nnm-2023-0207</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/nnm-2023-0207" target="_blank" >10.2217/nnm-2023-0207</a>

Result language
angličtina
Original language name
Elevated glutathione in researchers exposed to engineered nanoparticles due to potential adaptation to oxidative stress
Original language description
Aim: To find a practical biomonitoring method for researchers exposed to nanoparticles causing oxidative stress. Methods: In a continuation of a study in 2016–2018, biological samples (plasma, urine and exhaled breath condensate [EBC]) were collected in 2019–2020 from 43 researchers (13.8 ± 3.0 years of exposure) and 45 controls. Antioxidant status was assessed using glutathione (GSH) and ferric-reducing antioxidant power, while oxidative stress was measured as thiobarbituric acid reactive substances, all using spectrophotometric methods. Researchers’ personal nanoparticle exposure was monitored. Results: Plasma GSH was elevated in researchers both before and after exposure (p < 0.01), postexposure plasma GSH correlated with nanoparticle exposure, and GSH in EBC increased. Conclusion: The results suggest adaptation to chronic exposure to nanoparticles, as monitored by plasma and EBC GSH.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry

Project
<a href="/en/project/GA22-08358S" target="_blank" >GA22-08358S: Transcriptome changes and genome integrity in human subjects acutely and chronically exposed to nanoparticles</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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