Dimetindene-Is the minimum toxic dose for children too strict?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F24%3A00584870" target="_blank" >RIV/61388955:_____/24:00584870 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10480214 RIV/00064165:_____/24:10480214
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/bcpt.14005" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/bcpt.14005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bcpt.14005" target="_blank" >10.1111/bcpt.14005</a>
Alternative languages
Result language
angličtina
Original language name
Dimetindene-Is the minimum toxic dose for children too strict?
Original language description
Dimetindene is a sedating antihistamine indicated for the symptomatic treatment of allergic conditions. Dimetindene is marketed among others under the trade name Fenistil (oral solution). Toxicity data are limited, and there is no consensus on the dose at which children require hospitalization. Objective is to determine the potentially toxic dose in children. Data in children with age up to 15 years were obtained from hospital discharge reports. Of 139 paediatric hospital discharge reports, 23 cases (16.5%) were excluded because of uncertain ingestion. In 116 children (46 boys and 70 girls, mean age 2 years and 9 months +/- 1 year and 1 month), the majority of children developed no symptoms (87 children, 75%, mean age 3 years +/- 1 year) and the remaining 29 children (25%, mean age 2 years and 11 months +/- 1 year and 3 months) developed only mild and spontaneously resolving symptoms of poisoning after a dose of 0.82 +/- 0.32 mg/kg b.w. (range 0.26-1.82 mg/kg). In 98% of all cases, hospitalized children were observed for a maximum 24 h, and their condition did not require specific treatment. In conclusion, the prognosis for accidental dimetindene poisoning in children appears to be good and the minimum toxic dose has been determined to be 0.5 mg/kg b.w.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Basic & Clinical Pharmacology & Toxicology
ISSN
1742-7835
e-ISSN
1742-7843
Volume of the periodical
134
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
750-755
UT code for WoS article
001189182500001
EID of the result in the Scopus database
2-s2.0-85189154340