Cell surface morphology mimicking nano-bio platform for immune cell stimulation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F24%3A00600622" target="_blank" >RIV/61388955:_____/24:00600622 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/24:43930389
Result on the web
<a href="https://hdl.handle.net/11104/0357936" target="_blank" >https://hdl.handle.net/11104/0357936</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.isci.2024.111033" target="_blank" >10.1016/j.isci.2024.111033</a>
Alternative languages
Result language
angličtina
Original language name
Cell surface morphology mimicking nano-bio platform for immune cell stimulation
Original language description
Studying the complex realm of cellular communication and interactions by fluorescence microscopy requires sample fixation on a transparent substrate. To activate T cells, which are pivotal in controlling the immune system, it is important to present the activating antigen in a spatial arrangement similar to the nature of the antigen-presenting cell, including the presence of ligands on microvilli. Similar arrangement is predicted for some other immune cells. In this work, immune cell-stimulating platform based on nanoparticle-ligand conjugates have been developed using a scalable, affordable, and broadly applicable technology, which can be readily deployed without the need for state-of-the-art nanofabrication instruments. The validation of surface biofunctionalization was performed by combination of fluorescence and atomic force microscopy techniques. We demonstrate that the targeted system serves as a biomimetic scaffold on which immune cells make primary contact with the microvilli-mimicking substrate and exhibit stimulus-specific activation.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
iScience
ISSN
2589-0042
e-ISSN
2589-0042
Volume of the periodical
27
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
111033
UT code for WoS article
001341080900001
EID of the result in the Scopus database
2-s2.0-85207803981