Role of Lipids in Morphogenesis of T-Cell Microvilli

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F21%3A00541309" target="_blank" >RIV/61388955:_____/21:00541309 - isvavai.cz</a>

Result on the web

<a href="http://hdl.handle.net/11104/0318885" target="_blank" >http://hdl.handle.net/11104/0318885</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2021.613591" target="_blank" >10.3389/fimmu.2021.613591</a>

Result language

angličtina

Original language name

Role of Lipids in Morphogenesis of T-Cell Microvilli

Original language description

T cells communicate with the environment via surface receptors. Cooperation of surface receptors regulates T-cell responses to diverse stimuli. Recently, finger-like membrane protrusions, microvilli, have been demonstrated to play a role in the organization of receptors and, hence, T-cell activation. However, little is known about the morphogenesis of dynamic microvilli, especially in the cells of immune system. In this review, I focus on the potential role of lipids and lipid domains in morphogenesis of microvilli. Discussed is the option that clustering of sphingolipids with phosphoinositides at the plasma membrane results in dimpling (curved) domains. Such domains can attract phosphoinositide-binding proteins and stimulate actin cytoskeleton reorganization. This process triggers cortical actin opening and bundling of actin fibres to support the growing of microvilli. Critical regulators of microvilli morphogenesis in T cells are unknown. At the end, I suggest several candidates with a potential to organize proteins and lipids in these structures.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/GA19-07043S" target="_blank" >GA19-07043S: Topological regulation of CD4 and CD8 in T cells</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

1664-3224

Volume of the periodical

12

Issue of the periodical within the volume

MAR 2021

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

613591

UT code for WoS article

000631856900001

EID of the result in the Scopus database

2-s2.0-85103068254