Dynamic microvilli sculpt bristles at nanometric scale
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F24%3A00139937" target="_blank" >RIV/00216224:14110/24:00139937 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41467-024-48044-3" target="_blank" >https://www.nature.com/articles/s41467-024-48044-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-024-48044-3" target="_blank" >10.1038/s41467-024-48044-3</a>
Alternative languages
Result language
angličtina
Original language name
Dynamic microvilli sculpt bristles at nanometric scale
Original language description
Organisms generate shapes across size scales. Whereas patterning and morphogenesis of macroscopic tissues has been extensively studied, the principles underlying the formation of micrometric and submicrometric structures remain largely enigmatic. Individual cells of polychaete annelids, so-called chaetoblasts, are associated with the generation of chitinous bristles of highly stereotypic geometry. Here we show that bristle formation requires a chitin-producing enzyme specifically expressed in the chaetoblasts. Chaetoblasts exhibit dynamic cell surfaces with stereotypical patterns of actin-rich microvilli. These microvilli can be matched with internal and external structures of bristles reconstructed from serial block-face electron micrographs. Individual chitin teeth are deposited by microvilli in an extension-disassembly cycle resembling a biological 3D printer. Consistently, pharmacological interference with actin dynamics leads to defects in tooth formation. Our study reveals that both material and shape of bristles are encoded by the same cell, and that microvilli play a role in micro- to submicrometric sculpting of biomaterials.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/NU22J-08-00062" target="_blank" >NU22J-08-00062: High throughput cancer cell mechanic and morphologic phenotyping during shear stress: predictor of migratory and invasive potential</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
2041-1723
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
1-9
UT code for WoS article
001221986200032
EID of the result in the Scopus database
2-s2.0-85192949204