Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F07%3A00087416" target="_blank" >RIV/61388963:_____/07:00087416 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7

Original language description

Solid-phase synthesis and some pharmacological properties of twenty new oxytocin analogues are described. Analogues are modified in position 7 by introduction of alpha-aminoisobutyric acid [Aib], L- or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid [L/D-Tic], L-alpha-t-butylglycine [Gly(Bu(t))] and pipecolic acid [Pip].

Czech name

Analoga oxytocinu obsahující konformačně omezené aminokyselinové zbytky v posici 7

Czech description

Popsána syntéza a některé biologické aktivity 20 nových analogů oxytocinu s hlavní modifikací v poloze 7 substituce prolinu alpha-aminoisomáselnou kyselinou[Aib], L- or D-1,2,3,4-tetrahydroisoquinolinovou -3-karboxylovou kyselinou [L/D-Tic], L-alpha-t-butylglycinem [Gly(Bu(t))] a kyselinou pipekolovou [Pip].

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Medicinal Chemistry

ISSN

0223-5234

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

6

Country of publishing house

FR - FRANCE

Number of pages

8

Pages from-to

799-806

UT code for WoS article

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EID of the result in the Scopus database

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