Synthesis and biological activity of oxytocin analogues containing unnatural amino acids in position 9: structure activity study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F10%3A00342937" target="_blank" >RIV/61388963:_____/10:00342937 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Synthesis and biological activity of oxytocin analogues containing unnatural amino acids in position 9: structure activity study

Original language description

The paper reports the solid phase synthesis and pharmacological properties of 24 oxytocin analogues. Basic modifications at position 9 (L- nebo D-beta-(2-thienyl)-alanine, L- or D-3-Pyridylalanine) were combined with D-tyrosine(OEthyl) or D-1-naphthylalanine in position 2 and beta-mercaptopropionic acid in position 1. Additional 8 analogues had alpha-aminoisobutyric acid or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in position 9. The analogue having the highest anti-oxytocic activity was [Mpa(1), D: -Tyr(Et)(2), Deg(9)]OT (pA2= 8.68).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Amino Acids

ISSN

0939-4451

e-ISSN

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Volume of the periodical

38

Issue of the periodical within the volume

5

Country of publishing house

AT - AUSTRIA

Number of pages

11

Pages from-to

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UT code for WoS article

000277133900030

EID of the result in the Scopus database

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