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Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F08%3A00305805" target="_blank" >RIV/61388963:_____/08:00305805 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells

  • Original language description

    DNA methylation inhibitors are being extensively studied as potential anticancer agents. In the present study, we compared the capability of alpha anomer of 5-aza-2'-deoxycytidine(alpha-5-azadCyd) to induce down-regulation of hTERT expression in HL-60 cells with other nucleoside analogs that act as DNA methylation inhibitors: beta-5-azadCyd (decitabine), (S)-9-(2,3-dihydroxypropyl)adenine [(S)-DHPA], isobutyl ester of (R,S)-3-(adenin-9-yl)-2-hydroxypropanoic acid [(R,S)-AHPA-ibu] and prospective DNA methylation inhibitors (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine [(S)-HPMPazaC] and 5-fluoro-zebularine (F-PymRf).

  • Czech name

    Alfa anomer 5-aza-2'-deoxycytidinu snižuje expresi hTERT mRNA expression v lidských leukemických buňkách HL-60

  • Czech description

    Inhibitory DNA metylace jsou studovány jako slibná protinádorová léčiva. V této práci srovnáváme schopnost alfa anomeru 5-aza-2'-deoxycytidinu(alfa-5-azadCyd) potlačit expresi telomerázy, enzymu, jehož zvýšená exprese je prokazatelná až u 90 % maligníchnádorů, s ostatními analogy nukleosidů majícími hypometylační účinky: beta-5-azadCyd (decitabin), (S)-9-(2,3-dihydroxypropyl)adenin [(S)-DHPA], izobutyl ester (R,S)-3-(adenin-9-yl)-2-hydroxypropanové kyseliny [(R,S)-AHPA-ibu] a perspektivních inhibitorůDNA metylace (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosinu [(S)-HPMPazaC] and 5-fluoro-zebularinu (F-PymRf).

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochemical Pharmacology

  • ISSN

    0006-2952

  • e-ISSN

  • Volume of the periodical

    75

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    965-972

  • UT code for WoS article

  • EID of the result in the Scopus database