Acyclic Nucleoside Phosphonates Bearing (R)- or (S)-9-[3-Hydroxy-2-(phosphonoethoxy)propyl] (HPEP) Moiety as Monomers for the Synthesis of Modified Oligonucleotides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00495572" target="_blank" >RIV/61388963:_____/18:00495572 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ejoc.201800490" target="_blank" >http://dx.doi.org/10.1002/ejoc.201800490</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.201800490" target="_blank" >10.1002/ejoc.201800490</a>
Alternative languages
Result language
angličtina
Original language name
Acyclic Nucleoside Phosphonates Bearing (R)- or (S)-9-[3-Hydroxy-2-(phosphonoethoxy)propyl] (HPEP) Moiety as Monomers for the Synthesis of Modified Oligonucleotides
Original language description
Suitably protected (R)- and (S)-HPEP {9-[3-hydroxy-2-(phosphonoethoxy)propyl]} derivatives containing adenine and thymine nucleobases were prepared as monomers for the introduction of acyclic nucleotide units into oligonucleotides. The solid phase synthesis of a series of ribo and 2-deoxyribo nonamers containing (R)-HPEP and (S)-HPEP units was successfully performed in both 5' → 3' and 3' → 5' directions. The measurement of thermal characteristics of the complexes of modified nonamers with complementary DNA and RNA strands revealed a general destabilizing effect of the introduced acyclic units on the thermal stability, but in several cases [(modif.)RNA*RNA and (modif.)DNA*RNA with (S)-HPEPA units], the duplexes were characterized in terms of Tm values.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Organic Chemistry
ISSN
1434-193X
e-ISSN
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Volume of the periodical
2018
Issue of the periodical within the volume
37
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
5119-5126
UT code for WoS article
000446662900006
EID of the result in the Scopus database
2-s2.0-85052603268