Nucleoside phosphonic acids in thymidine phosphorylase inhibition: Structure - activity relationship
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F08%3A00312445" target="_blank" >RIV/61388963:_____/08:00312445 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Nucleoside phosphonic acids in thymidine phosphorylase inhibition: Structure - activity relationship
Original language description
A number of structurally diverse nucleosides phosphonic acids have been tested against human recombinant thymidine phosphorylase and human platelets supernatant using 2'-deoxy-5-nitrouridine as the substrate. We have selected several inhibitors working at micromolar level as lead structures for further evaluation.
Czech name
Nukleosidfosfonové kyseliny jako inhibitory thymidinfosforylázy: vztah struktury a aktivity
Czech description
Řada strukturně odlišných nukleosidfosfonových kyselin byla testována v interakci s rekombinantní thymidinfosforylázou a supernatantem lidských krevních destiček za užití 2'-deoxy-5-nitrouridinu jako substrátu. Bylo nalezeno několik inhibitorů působícíchna mikromolární úrovni jakožto klíčové struktury pro další studium.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nucleic Acids Symposium Series
ISSN
0261-3166
e-ISSN
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Volume of the periodical
-
Issue of the periodical within the volume
52
Country of publishing house
GB - UNITED KINGDOM
Number of pages
2
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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