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Design and synthesis of 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase
We report on a series of novel 5,6-disubstituted uracils with significant inhibitory activity against human and Escherichia coli thymidine phosphorylases....
CC - Organická chemie
- 2005 •
- D
Rok uplatnění
D - Stať ve sborníku
Comparative analysis of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in colorectal cancer and surrounding normal tissue
thymidylate synthase, thymidine phosphorylase...
ED - Fyziologie
- 2005 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines
A series of thymine phosphonomethoxyalkyl derivatives were evaluated for their ability to inhibit thymidine phosphorylase (dThdPase) purified from rat spontaneous T-cell lymphoma....
CC - Organická chemie
- 2005 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Novel nucleoside phosphonic acids-based inhibitors of thymidine phosphorylase
Several sugar-modified thymine-containing nucleoside phosphonic acids were found as a strong inhibitors of thymidine phosphorylase purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain....
CC - Organická chemie
- 2005 •
- D
Rok uplatnění
D - Stať ve sborníku
Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase
for their ability to inhibit the human thymidine phosphorylase expressed in V79 Chinese hamster cells,as well as thymidine phosphorylase from SD-lymphoma, Escherichia coli a considerable inhibitory activity toward...
CC - Organická chemie
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase
We report on a series of novel 5,6-disubstituted uracils with significant inhibitory activity against human and Escherichia coli thymidine phosphorylases. Bis-uracil conjugates were identified as the most potent inhibitors of TPs in...
CC - Organická chemie
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase
We have discovered that 6-halouracils substituted at position C5 by certain hydrophobic groups exhibit significant inhibitory activity against human thymidine phosphorylase. The most potent compounds bear a five- or six-membered cyc...
CC - Organická chemie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Nucleoside phosphonic acids in thymidine phosphorylase inhibition: Structure - activity relationship
A number of structurally diverse nucleosides phosphonic acids have been tested against human recombinant thymidine phosphorylase and human platelets supernatant using 2'-deoxy-5-nitrouridine as the substrate. We have selected severa...
CC - Organická chemie
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Syntheses of base and side-chain modified pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma
aspotent inhibitors of thymidine phosphorylase. While the 5-fluorouracil derivatives toward thymidine phosphorylase from rat spontaneous T-cell lymphoma....
CC - Organická chemie
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma
. The obtained compounds exhibit a considerable inhibitory potency of thymidine phosphorylase inhibitors of E. coli and human thymidine phosphorylase....
CC - Organická chemie
- 2007 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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