Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp3-hybridised C-5 carbon atom

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F09%3A00328907" target="_blank" >RIV/61388963:_____/09:00328907 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp3-hybridised C-5 carbon atom
Original language description
Anotace angl: The proton to deuterium exchange reaction of hydrogen atom in position 5 of the fifteen pyrimidine derivatives was studied. The exchange proceeds under both acidic and alkaline conditions: under acidic conditions, the mechanism involves protonation at position 5 (forming a s-complex), whereas under alkaline conditions, the exchange is caused mainly by the equilibrium of the tautomers involving one tautomer with a sp3 -hybridised carbon atom in position 5.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/KJB400550903" target="_blank" >KJB400550903: Study of isotopic exchange of hydrogen in the position 5 of pyrimidine derivatives and synthesis of pyrimidines with biological activity labeled with tritium.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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