Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F10%3A00342537" target="_blank" >RIV/61388963:_____/10:00342537 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation

Original language description

The aim of this study was to determine the impact of two anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons located in the arcuate (ARC) and ventromedial (VMN) nucleiand hypocretin (Hcrt) synthesizing neurons located in the lateral hypothalamic area (LHA). After overnight starvation, male C57Bl/6 mice received in the morning saline (SAL), CCK (4 ?g/kg, i.p.), CART peptide (0.1 ?g/mice, i.c.v.) or CCK followed 5 minutes later by CART peptide. After 60 min, the presence of Fos or Fos-Hcrt immunostainings signalized the effect of treatments on the cell activity in ARC and VMN, as well as Hcrt cell activity in the LHA. The results indicate that CCK may modify the effectof CART peptide and thus substantially influence the activity of neurons in the hypothalamic structures involved in the food intake regulation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GA303%2F05%2F0614" target="_blank" >GA303/05/0614: Central and peripheral pathways underlying feeding-related effects of cocaine and amphetamine regulated transcript (CART) peptides</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Peptides

ISSN

0196-9781

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

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UT code for WoS article

000274375500019

EID of the result in the Scopus database

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