Anorexigenic effect of cholecystokinin is lost but that of CART (cocaine and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F09%3A00333492" target="_blank" >RIV/61388971:_____/09:00333492 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/09:00333492

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Anorexigenic effect of cholecystokinin is lost but that of CART (cocaine and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice

Original language description

Monosodium glutamate (MSG) treatment of neonatal mice results in a selective damage to the arcuate nucleus (ARC) and development of obesity. The MSG obese mice do not respond to fasting by an increased food intake which makes difficult to measure the effect of peptides attenuating food intake such as cholecystokinin (CCK) or cocaine- and amphetamine-regulated transcript (CART) peptide. However, orexigenic effect of NPY is preserved in the fed MSG obese rodents. In this study with fed lean and MSG obeseC57BL/6 male mice, short-term food intake was measured after simultaneous central administration of orexigenic NPY with either CART peptide or peripherally administered CCK. Anorexigenic action of exogenous CART peptide was preserved in MSG obese mice. On the other hand, satiety effect of exogenous CCK was completely lost in MSG obese mice probably because of ineffective leptin signaling in ARC.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/GA303%2F05%2F0614" target="_blank" >GA303/05/0614: Central and peripheral pathways underlying feeding-related effects of cocaine and amphetamine regulated transcript (CART) peptides</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

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UT code for WoS article

000272080200013

EID of the result in the Scopus database

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