Synthesis and GABAA receptor activity of A-homo analogues of neuroactive steroids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F10%3A00346335" target="_blank" >RIV/61388963:_____/10:00346335 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/10:00001063
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Synthesis and GABAA receptor activity of A-homo analogues of neuroactive steroids
Original language description
A-Homo-5-pregnenes were prepared and their inhibition of binding TBPS to GABAA receptors was measured. 3alpha-Hydroxy and 4alpha-hydroxy analogues of allopregnanolone were slightly active while the 3beta-hydroxy analogue was almost as active as allopregnanolone. Reduction of the double bond of the latter compound resulted in a ten fold loss of activity.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F08%2F1498" target="_blank" >GA203/08/1498: Synthesis and activity evaluation of NMDA receptor antagonists</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Medicinal Chemistry
ISSN
0223-5234
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
7
Country of publishing house
FR - FRANCE
Number of pages
7
Pages from-to
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UT code for WoS article
000278626400044
EID of the result in the Scopus database
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