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Synthesis and GABAA receptor activity of A-homo analogues of neuroactive steroids

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F10%3A00346335" target="_blank" >RIV/61388963:_____/10:00346335 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023752:_____/10:00001063

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis and GABAA receptor activity of A-homo analogues of neuroactive steroids

  • Original language description

    A-Homo-5-pregnenes were prepared and their inhibition of binding TBPS to GABAA receptors was measured. 3alpha-Hydroxy and 4alpha-hydroxy analogues of allopregnanolone were slightly active while the 3beta-hydroxy analogue was almost as active as allopregnanolone. Reduction of the double bond of the latter compound resulted in a ten fold loss of activity.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA203%2F08%2F1498" target="_blank" >GA203/08/1498: Synthesis and activity evaluation of NMDA receptor antagonists</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Medicinal Chemistry

  • ISSN

    0223-5234

  • e-ISSN

  • Volume of the periodical

    45

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    FR - FRANCE

  • Number of pages

    7

  • Pages from-to

  • UT code for WoS article

    000278626400044

  • EID of the result in the Scopus database