A new route alpha-alkyl-alpha-fluoromethylenebisphosphonates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F11%3A00360949" target="_blank" >RIV/61388963:_____/11:00360949 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/c1ob05095h" target="_blank" >http://dx.doi.org/10.1039/c1ob05095h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c1ob05095h" target="_blank" >10.1039/c1ob05095h</a>

Result language
angličtina
Original language name
A new route alpha-alkyl-alpha-fluoromethylenebisphosphonates
Original language description
A new route to alpha-alkyl-alpha-fluoromethylenebisphosphonates (2) has been developed starting from commercially available tetraethyl fluoromethylenebisphosphonate (1), and alkyl halides using either cesium carbonate in DMF or sodium dimsyl. De-esterification of 2 provided biologically important alpha-alkyl-alpha-fluoromethylenebisphosphonic acid (3), while alkoxide?induced carbon?phosphorus bond cleavage of 2 gave alfa-fluorophosphonates (4), which are useful synthons in organic synthesis.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/GP203%2F08%2FP310" target="_blank" >GP203/08/P310: Nucleophilic introduction of fluorinated groups using organo-phosphorus compounds</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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