A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F11%3A00363152" target="_blank" >RIV/61388963:_____/11:00363152 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/11:00363152
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejmech.2011.05.040" target="_blank" >http://dx.doi.org/10.1016/j.ejmech.2011.05.040</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmech.2011.05.040" target="_blank" >10.1016/j.ejmech.2011.05.040</a>

Result language
angličtina
Original language name
A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities
Original language description
A novel and efficient method for the one-pot synthesis of diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates, starting from free phosphonic acids or phosphonate diesters is reported. The methodology has been applied to the synthesis of thepotent anticancer agent GS-9219, and symmetrical bis-amidates of other biologically active phosphonic acids.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/VG20102015046" target="_blank" >VG20102015046: Targeted drug design for bioterrorism prevention. Development of effective inhibitors of the adenylate cyclase toxin of Bordetella pertusis and Bacillus anthracis.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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