6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F11%3A00363423" target="_blank" >RIV/61388963:_____/11:00363423 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs
Original language description
Plasmodium falciparum and Plasmodium vivax are the predominant causative agents of malaria. One metabolic pathway crucial for the survival and replication and survival of the parasite is the synthesis of the purine nucleoside monophosphates. The focus ofthis review is on the identification and characterization of inhibitors of the key enzyme in this pathway - 6-oxopurine phosphoribosyltransferase. The acyclic nucleoside phosphonates (ANPs) appear to be excellent candidates that can be selective compared to the human enzyme.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/1M0508" target="_blank" >1M0508: New Antivirals and Antineoplastics</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Topics in Medicinal Chemistry
ISSN
1568-0266
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
16
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
18
Pages from-to
2085-2102
UT code for WoS article
000293858200008
EID of the result in the Scopus database
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