Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F11%3A00369985" target="_blank" >RIV/61388963:_____/11:00369985 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1135/cccc2011152" target="_blank" >http://dx.doi.org/10.1135/cccc2011152</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1135/cccc2011152" target="_blank" >10.1135/cccc2011152</a>

Result language
angličtina
Original language name
Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties
Original language description
We report on the preparation of novel 1?-homonucleoside derivatives locked in a West conformation by 1?,4?-bridge consisting of annulated benzene or naphthalene ring. The crucial step of the synthesis was Diels-Alder reaction of an appropriate aryne witha suitable furane derivative. Antiviral properties of novel compounds were studied and slight activity against HCV was detected in several compounds.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/1M0508" target="_blank" >1M0508: New Antivirals and Antineoplastics</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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