Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogues as potential antimalarial agents

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00376074" target="_blank" >RIV/61388963:_____/12:00376074 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.bmc.2011.12.034" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2011.12.034</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmc.2011.12.034" target="_blank" >10.1016/j.bmc.2011.12.034</a>

Result language

angličtina

Original language name

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogues as potential antimalarial agents

Original language description

Iso-HPMPHx and iso-HPMPG were found as effective inhibitors of both the Pf and Pv enzymes HGXPRT. iso-HPMPHx shows the highest selectivity. A series of side-chaim modified analogues of both compounds was also prepared.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic & Medicinal Chemistry

ISSN

0968-0896

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1222-1230

UT code for WoS article

000299535400007

EID of the result in the Scopus database

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