Involvement of MAP Kinases in the Cytotoxicity of Acyclic Nucleoside Phosphonates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00376351" target="_blank" >RIV/61388963:_____/12:00376351 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Involvement of MAP Kinases in the Cytotoxicity of Acyclic Nucleoside Phosphonates
Original language description
The role of ERK, p38, JNK and AKT kinases in PMEG-induced apoptosis was investigated in CCRF-CEM and HL-60 leukemia cells. First, MAPK mRNA and protein expression were assessed in PMEG-treated cells. MAPK activation was then measured using phospho-specific antibodies. Up-regulation of p38beta, gamma and delta mRNA were observed following PMEG treatment of CCRF-CEM cells, however, the total protein expression remained unchanged. Neither PMEG nor its analogue 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP) induced p38 kinase phosphorylation in CCRF-CEM cells, whereas increased p38 phosphorylation was observed in HL-60 cells. The ERK, JNK or AKT pathways did not. PMEG- and PMEDAP-induced cytotoxicity is therefore partly mediated by the p38 pathway in human leukemia cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/1M0508" target="_blank" >1M0508: New Antivirals and Antineoplastics</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anticancer Research
ISSN
0250-7005
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
2
Country of publishing house
GR - GREECE
Number of pages
6
Pages from-to
497-502
UT code for WoS article
000299985800013
EID of the result in the Scopus database
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