Insulin and Insulin-like Growth Factor II Differentially Regulate Endocytic Sorting and Stability of Insulin Receptor Isoform A

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00376582" target="_blank" >RIV/61388963:_____/12:00376582 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1074/jbc.M111.252478" target="_blank" >http://dx.doi.org/10.1074/jbc.M111.252478</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1074/jbc.M111.252478" target="_blank" >10.1074/jbc.M111.252478</a>

Result language

angličtina

Original language name

Insulin and Insulin-like Growth Factor II Differentially Regulate Endocytic Sorting and Stability of Insulin Receptor Isoform A

Original language description

Insulin-like growth factor (IGF) II interacts with IR-A and is a more powerful mitogen than insulin. IGF-II and insulin differ in regulating insulin receptor (IR)-A trafficking and stability. Compared with insulin, IGF-II induces lower IR-A and downstream effectors activation but protects IR-A and IRS-1 from down-regulation, thereby evoking a sustained mitogenic stimulus.These results further elucidate the mechanisms controlling IR-A biological responses.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Biological Chemistry

ISSN

0021-9258

e-ISSN

—

Volume of the periodical

287

Issue of the periodical within the volume

14

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

11422-11436

UT code for WoS article

000302780100071

EID of the result in the Scopus database

—