5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00377427" target="_blank" >RIV/61388963:_____/12:00377427 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4155/FMC.12.36" target="_blank" >http://dx.doi.org/10.4155/FMC.12.36</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4155/FMC.12.36" target="_blank" >10.4155/FMC.12.36</a>

Result language
angličtina
Original language name
5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives
Original language description
The review summarizes the basic milestones of research of 5-azacytosine nucleosides, and their mechanism of action as inhibitors of DNA methylations. Compounds decitabine and 5-azacytidine became clinically used drugs. The second part of the review is paid to 5-azacytosine acyclic nucleoside analogues and phosphonomethyl derivatives as anti-DNA virus agents.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/FR-TI4%2F625" target="_blank" >FR-TI4/625: New derivatives of 5-azacytosine nucleosides like demethylating therapeutics: identification of clinical candidates and efficiency biomarkers.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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