Synthesis and Photophysical Properties of Biaryl-Substituted Nucleos(t)ides. Polymerase Synthesis of DNA Probes Bearing Solvatochromic and pH Sensitive Dual Fluorescent and 19F NMR Labels
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00377722" target="_blank" >RIV/61388963:_____/12:00377722 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/jo202321g" target="_blank" >http://dx.doi.org/10.1021/jo202321g</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jo202321g" target="_blank" >10.1021/jo202321g</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and Photophysical Properties of Biaryl-Substituted Nucleos(t)ides. Polymerase Synthesis of DNA Probes Bearing Solvatochromic and pH Sensitive Dual Fluorescent and 19F NMR Labels
Original language description
The design of four new fluorinated biaryl fluorescent labels and their attachment to nucleosides and nucleoside triphosphates (dNTPs) by the aqueous cross-coupling reactions of biarylboronates is reported. The modified dNTPs were good substrates for KODXL polymerase and were enzymatically incorporated into DNA probes. The photophysical properties of the biaryl-modified nucleosides, dNTPs, and DNA were studied systematically. Some labels were used for detection of secondary structure changes, mismatch pairing or pH microenvironment.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F09%2F0317" target="_blank" >GA203/09/0317: Construction of novel functional nucleic acids for applications in chemical biology, catalysis and self assembly.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Organic Chemistry
ISSN
0022-3263
e-ISSN
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Volume of the periodical
77
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
19
Pages from-to
1026-1044
UT code for WoS article
000299238400024
EID of the result in the Scopus database
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