Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00378633" target="_blank" >RIV/61388963:_____/12:00378633 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1021/jm300662d" target="_blank" >http://dx.doi.org/10.1021/jm300662d</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/jm300662d" target="_blank" >10.1021/jm300662d</a>

Result language

angličtina

Original language name

Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases

Original language description

Series of novel acyclic nucleoside phosphonates - aza-ANPs - was designed as potent and selective inhibitors of 6-oxopurine phosphoribosyltransferases, crucial enzyme for the survival of malarial parasites.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Medicinal Chemistry

ISSN

0022-2623

e-ISSN

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Volume of the periodical

55

Issue of the periodical within the volume

13

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

6209-6223

UT code for WoS article

000306259400017

EID of the result in the Scopus database

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