Structure of the immature retroviral capsid at 8 angstrom resolution by cryo-electron microscopy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00381079" target="_blank" >RIV/61388963:_____/12:00381079 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/12:43894097

Result on the web

<a href="http://dx.doi.org/10.1038/nature11169" target="_blank" >http://dx.doi.org/10.1038/nature11169</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/nature11169" target="_blank" >10.1038/nature11169</a>

Result language

angličtina

Original language name

Structure of the immature retroviral capsid at 8 angstrom resolution by cryo-electron microscopy

Original language description

The assembly of retroviruses such as HIV-1 is driven by oligomerization of their major structural protein, Gag. Gag is a multi-domain polyprotein including three conserved folded domains MA (matrix), CA (capsid) and NC (nucleocapsid). Assembly of an infectious virion proceeds in two stages. In the first stage, Gag oligomerization into a hexameric protein lattice leads to formation of an incomplete, roughly spherical protein shell that buds through the plasma membrane of the infected cell to release an enveloped immature virus particle. In the second stage, cleavage of Gag by the viral protease leads to rearrangement of the particle interior, converting the non-infectious immature virus particle into a mature infectious virion. The immature Gag shell acts as the pivotal intermediate in assembly and is a potential target for anti-retroviral drugs both to inhibit virus assembly and to disrupt virus maturation. Detailed structural information on the immature Gag shell has not been availabl

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature

ISSN

0028-0836

e-ISSN

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Volume of the periodical

487

Issue of the periodical within the volume

7407

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

385-389

UT code for WoS article

000306506500047

EID of the result in the Scopus database

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