Bioportide: an emergent concept of bioactive cell-penetrating peptides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00381127" target="_blank" >RIV/61388963:_____/12:00381127 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00018-012-0979-4" target="_blank" >http://dx.doi.org/10.1007/s00018-012-0979-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00018-012-0979-4" target="_blank" >10.1007/s00018-012-0979-4</a>

Result language
angličtina
Original language name
Bioportide: an emergent concept of bioactive cell-penetrating peptides
Original language description
Cell-penetrating peptides (CPPs) have proven utility for the highly efficient intracellular delivery of bioactive cargoes that include peptides, proteins, and oligonucleotides. The many strategies developed to utilize CPPs solely as pharmacokinetic modifiers necessarily requires them to be relatively inert. Moreover, it is feasible to combine one or multiple CPPs with bioactive cargoes either by direct chemical conjugation or, more rarely, as non-covalent complexes. In terms of the message-address hypothesis, this combination of cargo (message) linked to a CPP (address) as a tandem construct conforms to the sychnological organization. More recently, we have introduced the term bioportide to describe monomeric CPPs that are intrinsically bioactive. Herein, we describe the design and biochemical properties of two rhegnylogically organized monometic CPPs that collectively modulate a variety of biological and pathophysiological phenomena. Thus, camptide, a cell-penetrant sequence located w
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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