Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00396383" target="_blank" >RIV/61388963:_____/13:00396383 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00396383 RIV/00216208:11140/13:10138966
Result on the web
<a href="http://dx.doi.org/10.1016/j.fitote.2013.05.025" target="_blank" >http://dx.doi.org/10.1016/j.fitote.2013.05.025</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fitote.2013.05.025" target="_blank" >10.1016/j.fitote.2013.05.025</a>
Alternative languages
Result language
angličtina
Original language name
Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties
Original language description
Three new and five known sesquiterpene lactones were isolated from the roots of Laser trilobum (L.) Borkh. Chemical identity of the known compounds and structural analysis of the new ones were determined by HR MS and NMR spectroscopy. The two new sesquiterpene lactones: 2-acetoxytrilobolide and 2-hydroxy-10-deacetyltrilobolide belong to the guaianolide type, and the third one, eudeslaserolide, to the biogenetically related eudesmanolide type. Both types, together with their biogenetic precursor of germacranolide type (laserolide) are present in L. trilobum, as well as in the related Laserpitium species. Purposefully selected set of these native sesquiterpene lactones was tested for specific immunobiological properties. The obtained results demonstratethat trilobolide and its acetoxy analog are strong activators of cytokine secretion. On the contrary, the other L. trilobum and Laserpitium siler constituents are only very mild activators, or even inhibitors of the cytokine and nitric ox
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA305%2F07%2F0061" target="_blank" >GA305/07/0061: Immunopharmacological potential of endoplasmic Ca(2+)-ATPase (SERCA) inhibitors</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Fitoterapia
ISSN
0367-326X
e-ISSN
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Volume of the periodical
89
Issue of the periodical within the volume
September
Country of publishing house
IT - ITALY
Number of pages
10
Pages from-to
157-166
UT code for WoS article
000323856500017
EID of the result in the Scopus database
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