Structural modification of trilobolide for upgrading its immunobiological properties and reducing its cytotoxic action
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F19%3A00505590" target="_blank" >RIV/61388963:_____/19:00505590 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/19:00505590 RIV/00216208:11140/19:10399941 RIV/60461373:22330/19:43917970
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0367326X18320987?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0367326X18320987?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fitote.2019.02.002" target="_blank" >10.1016/j.fitote.2019.02.002</a>
Alternative languages
Result language
angličtina
Original language name
Structural modification of trilobolide for upgrading its immunobiological properties and reducing its cytotoxic action
Original language description
Five new and three known sesquiterpene lactones were prepared by chemical transformation of trilobolide originally isolated from seeds of Laser trilobum (L.) Borkh. Chemical identity of the known compounds, and structural analysis of the new ones, were determined by HR MS and by 1H and 13C NMR spectroscopy. The new trilobolide derivatives were obtained by modification of the acyl substituent in the position C-8, the others by acetylating of the specific lactone diol moiety. The purposefully selected representative set of these trilobolide derivatives was tested for specific immunobiological properties. The obtained results demonstrated that trilobolide and some of its C-8 acyl analogs are strong activators of NO production, i.e. potent immunostimulatory agents. On contrary the C-8 deacyl derivative or the per-acetylated derivative are only very mild activators, or even inhibitors of the nitric oxide production.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/GA14-04329S" target="_blank" >GA14-04329S: Relationship between biological activities of sesquiterpene lactones to their subcellular localization</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Fitoterapia
ISSN
0367-326X
e-ISSN
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Volume of the periodical
134
Issue of the periodical within the volume
Apr
Country of publishing house
IT - ITALY
Number of pages
8
Pages from-to
88-95
UT code for WoS article
000468710300012
EID of the result in the Scopus database
2-s2.0-85061656778