Reactivity of Hydroxy and Amino Derivatives of 2-Phenyl-1H-imidazoline and 2-Phenyl-1H-imidazole toward Isocyanates: Synthesis of Appropriate Carbamates and Ureas

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00398765" target="_blank" >RIV/61388963:_____/13:00398765 - isvavai.cz</a>
Alternative codes found
RIV/61989100:27640/13:86087679 RIV/00216208:11160/13:10144052
Result on the web
<a href="http://dx.doi.org/10.1002/jhet.984" target="_blank" >http://dx.doi.org/10.1002/jhet.984</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jhet.984" target="_blank" >10.1002/jhet.984</a>

Result language
angličtina
Original language name
Reactivity of Hydroxy and Amino Derivatives of 2-Phenyl-1H-imidazoline and 2-Phenyl-1H-imidazole toward Isocyanates: Synthesis of Appropriate Carbamates and Ureas
Original language description
Reactivity of 2-(4-hydroxyphenyl)-1H-imidazoline and 2-(4-hydroxyphenyl)-1H-imidazole toward substituted phenyl isocyanates was studied. When mentioned imidazoline was treated with 2.5 equiv of substituted phenyl isocyanate, three N,O-dicarboxamides wereprepared (substituents are H, 4-NO2, and 4-CH3). Subsequently, N,O-diacetylated 2-(4-hydroxyphenyl)-1H-imidazoline was prepared and selective deprotection method was developed for preparation of 1-acetyl-2-(4-hydroxyphenyl)-1H-imidazoline using diethylamine in acetone. Six carbamates derived from this imidazoline were then prepared using 1.1 equiv of substituted phenyl isocyanates (substituents are H, 4-CH3, 4-OCH3, 4-NO2, 4-CN, and 3-CF3). Finally, two carbamates were prepared from 2-(4-hydroxyphenyl)-1H-imidazole (substituents are 4-NO2 and 4-CN). No reactivity to imidazole ring was observed in this case. Eight derivatives were subjected to antimycobacterial screening. Concurrently, reactivity of 2-(2-aminophenyl)- and 2-(2-hydroxyph
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/GA205%2F08%2F0869" target="_blank" >GA205/08/0869: Clay minerals as host matrices for functional nanostructures</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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