Cytotoxic Constituents of Pachyrhizus tuberosus from Peruvian Amazon

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00399185" target="_blank" >RIV/61388963:_____/13:00399185 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/13:61880 RIV/60460709:41340/13:61880 RIV/60461373:22330/13:43895414

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cytotoxic Constituents of Pachyrhizus tuberosus from Peruvian Amazon

Original language description

Investigations into the chemical constituents of the seeds of the neglected tuber crop Pachyrhizus tuberosus (Leguminosae) resulted in the isolation of seven components: five rotenoids [12a-hydroxyerosone (1), 12a-hydroxydolineone (2), erosone (3), 12a-hydroxyrotenone (4) and rotenone (6)], a phenylfuranocoumarin [pachyrrhizine (5)] and an isoflavanone [neotenone (7)]. The compounds were isolated using several chromatography techniques and characterized and verified by NMR and HPLC/MS. The MTT assay wasused to examine the selective cytotoxic effects of the methanolic P. tuberosus extract and isolated compounds in two human cancer cell lines [breast (MCF-7) and colorectal (HCT-116)] and in non-transformed human fibroblasts (MRC-5); IC50 values were calculated. The methanolic P. tuberosus extract displayed respectable cytotoxic effects against HCT-116 and MCF-7 cells with IC50 values of 7.3 and 6.3 mu g/mL, respectively. Of the compounds, 6 exacted greatest cytotoxicity and selectivity

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/GA525%2F09%2F0994" target="_blank" >GA525/09/0994: Chemotaxonomy of isoflavonoids</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Natural Product Communications

ISSN

1934-578X

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

1423-1426

UT code for WoS article

000326127900022

EID of the result in the Scopus database

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