Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00427769" target="_blank" >RIV/61388963:_____/14:00427769 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1530/JOE-13-0417" target="_blank" >http://dx.doi.org/10.1530/JOE-13-0417</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1530/JOE-13-0417" target="_blank" >10.1530/JOE-13-0417</a>
Alternative languages
Result language
angličtina
Original language name
Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue
Original language description
The metabolic action of oxytocin has recently been intensively studied to assess the ability of the peptide to regulate energy homeostasis. Despite the obvious weight-reducing effect of oxytocin observed in experimental studies, plasma oxytocin levels were found to be unchanged or even elevated in human obesity. The aim of our study was to evaluate the changes in the oxytocin system in Zucker rats, an animal model closely mirroring morbid obesity in humans. Plasma oxytocin levels were measured in obeseZucker rats and lean controls by enzyme immunoassay after plasma extraction. The expression of oxytocin and oxytocin receptor (OXTR) was assessed at the mRNA and protein levels by quantitative real-time PCR and immunoblotting respectively. Plasma and tissue activity of oxytocinase, the main enzyme involved in oxytocin degradation, were measured by fluorometric assay using an arylamide derivate as the substrate. Obese Zucker rats displayed a marked reduction in plasma oxytocin levels. Ele
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Endocrinology
ISSN
0022-0795
e-ISSN
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Volume of the periodical
220
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
333-343
UT code for WoS article
000332693200015
EID of the result in the Scopus database
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