MODULATION OF SYMPATHOADRENERGIC CONTRACTIONS BY PERIVASCULAR ADIPOSE TISSUE IN MESENTERIC ARTERIES OF RATS WITH DIFFERENT LEVEL OF BODY ADIPOSITY

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00550886" target="_blank" >RIV/67985823:_____/20:00550886 - isvavai.cz</a>

Result on the web

<a href="https://jpp.krakow.pl/journal/archive/08_20/pdf/10.26402/jpp.2020.4.14.pdf" target="_blank" >https://jpp.krakow.pl/journal/archive/08_20/pdf/10.26402/jpp.2020.4.14.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.26402/jpp.2020.4.14" target="_blank" >10.26402/jpp.2020.4.14</a>

Result language

angličtina

Original language name

MODULATION OF SYMPATHOADRENERGIC CONTRACTIONS BY PERIVASCULAR ADIPOSE TISSUE IN MESENTERIC ARTERIES OF RATS WITH DIFFERENT LEVEL OF BODY ADIPOSITY

Original language description

Obesity is associated with increased sympathetic nervous system activation, possibly contributing to higher cardiovascular risk. The aim of this study was to assess the relationship between body adiposity and sympathoadrenergic contractions in rat isolated mesenteric arteries, and the modulatory effect of mesenteric perivascular adipose tissue (PVAT). Experiments were performed on male 38-week-old Wistar, Zucker lean (ZL) and Zucker diabetic fatty (ZDF) rats. Paired rings of isolated rat superior mesenteric arteries with or without PVAT were prepared and connected to a force-displacement transducer for the recording of isometric tension. Contractile responses were elicited by increasing doses of exogenous noradrenaline and by endogenous noradrenaline released during electrical stimulation of perivascular adrenergic nerves. In ZDF rats, mesenteric PVAT had marked anticontractile effect leading to significant reduction in adrenergic contractions of their superior mesenteric arteries, however, in arterial preparations without PVAT, obese rats showed significantly increased sensitivity in their contractile responses to adrenergic stimulation when compared to other rat groups. In Wistar rats, ranging in the level of body adiposity between ZL and ZDF rats, neurogenic contractions in arterial preparations with preserved PVAT were higher compared to those without PVAT. No vasomodulatory effect of PVAT was detected in mesenteric arteries from ZL rats. The results of this study indicate that the modulatory effect of mesenteric PVAT on arterial adrenergic contractions did not change in proportion with increasing adiposity, however, it could be influenced by the rat strain-specific distribution of sympathetic nerves between PVAT and the proper mesenteric arterial wall. In ZDF rats, characterized by higher vascular sympathetic tone, the mesenteric arteries might be specifically regulated by the anticontractile effect of PVAT, leading to higher mesenteric blood flow. This could be associated with hyperphagia and increased nutrient-induced mesenteric vasodilatation in this rat strain.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30105 - Physiology (including cytology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Physiology and Pharmacology

ISSN

0867-5910

e-ISSN

—

Volume of the periodical

71

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

8

Pages from-to

589-596

UT code for WoS article

000607230500014

EID of the result in the Scopus database

2-s2.0-85097814717