Solvated States of Poly-L-alanine alpha-Helix Explored by Raman Optical Activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00429543" target="_blank" >RIV/61388963:_____/14:00429543 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/jp500794s" target="_blank" >http://dx.doi.org/10.1021/jp500794s</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jp500794s" target="_blank" >10.1021/jp500794s</a>

Result language
angličtina
Original language name
Solvated States of Poly-L-alanine alpha-Helix Explored by Raman Optical Activity
Original language description
Raman optical activity (ROA) reveals surprising details of the secondary structure of polypeptides and proteins in solution phase. Yet specific spectral features, such as in the extended amide III region of hydrated alpha-helix, did not seem explicable by the generally accepted sensitivity of ROA to the local conformation. This is reconciled in the present study by simulations of ROA spectra for model alpha-helical structures. Two positive ROA peaks often observed at around 1340 and 1300 cm(-1) for polypeptides and proteins have been assigned to two types of solvated alpha-helices; one is stable in hydrophilic environment where amide groups make hydrogen bonds to solvent molecules or polar side chains (similar to 1340 cm(-1)), and the other is supported by a hydrophobic environment without the possibility of external hydrogen bonds (similar to 1300 cm(-1)). For poly-L-alanine (PLA), regarded as a good model of a-helical structure, the experimentally observed relative intensity ratio of
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP208%2F11%2F0105" target="_blank" >GAP208/11/0105: Expanding the Optical Activity Method to the Realm of Biomolecules</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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