Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00430390" target="_blank" >RIV/61388963:_____/14:00430390 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ardp.201300431" target="_blank" >http://dx.doi.org/10.1002/ardp.201300431</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ardp.201300431" target="_blank" >10.1002/ardp.201300431</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position
Original language description
The synthesis of a novel library of purine derivatives bearing various bicyclic and polycylic substituents at the N-9 position is described. The series includes norbornanes, bicyclo[2.2.2] octanes, and bicyclo[3.2.1] octanes attached at the bridgehead position as well as bicyclo[3.1.1] heptanes, tetrahydro-1-naphthalenes, and adamantanes bonded either directly or via a linear chain to the 6-chloropurine nucleobase. A number of prepared derivatives exerted significant activity against the enterovirus. Despite attempts to correlate the activity against picornaviruses with their phosphatidylinositol 4-kinase KIII beta inhibitory activity, it is clear that the inhibition of this host factor cannot explain the observed antiviral potency.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP303%2F11%2F1297" target="_blank" >GAP303/11/1297: Mechanisms of antiviral and cytostatic effects of novel carbocyclic nucleoside analogs</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archiv der Pharmazie
ISSN
0365-6233
e-ISSN
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Volume of the periodical
347
Issue of the periodical within the volume
7
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
478-485
UT code for WoS article
000338940600003
EID of the result in the Scopus database
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