Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00435088" target="_blank" >RIV/61388963:_____/14:00435088 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/14:00435088

Result on the web

<a href="http://dx.doi.org/10.1107/S1399004713030502" target="_blank" >http://dx.doi.org/10.1107/S1399004713030502</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1107/S1399004713030502" target="_blank" >10.1107/S1399004713030502</a>

Result language

angličtina

Original language name

Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors

Original language description

The human 5'(3')-deoxyribonucleotidases catalyze the dephosphorylation of deoxyribonucleoside monophosphates to the corresponding deoxyribonucleosides and thus help to maintain the balance between pools of nucleosides and nucleotides. Here, the structures of human cytosolic odeoxyribonucleotidase (cdN) at atomic resolution (1.08 angstrom) and mitochondrial deoxyribonucleotidase (mdN) at near-atomic resolution (1.4 angstrom) are reported. The attainment of an atomic resolution structure allowed interatomic distances to be used to assess the probable protonation state of the phosphate anion and the side chains in the enzyme active site. A detailed comparison of the cdN and mdN active sites allowed the design of a cdN-specific inhibitor.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA203%2F09%2F0820" target="_blank" >GA203/09/0820: Structure based drug design of specific nucleotidases inhibitors, potentially pharmacologically important compounds.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Crystallographica Section D-Biological Crystallography

ISSN

0907-4449

e-ISSN

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Volume of the periodical

70

Issue of the periodical within the volume

February

Country of publishing house

DK - DENMARK

Number of pages

10

Pages from-to

461-470

UT code for WoS article

000331554500025

EID of the result in the Scopus database

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