N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00435700" target="_blank" >RIV/61388963:_____/14:00435700 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/14:43898163

Result on the web

<a href="http://dx.doi.org/10.1111/fcp.12085" target="_blank" >http://dx.doi.org/10.1111/fcp.12085</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/fcp.12085" target="_blank" >10.1111/fcp.12085</a>

Result language

angličtina

Original language name

N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis

Original language description

Many of disease-modifying anti-rheumatic drugs often have side effects at high doses and/or during long-term administration. Increased efficacy without increased toxicity is expected for combination therapy of rheumatoid arthritis (RA). The aim of the study was to examine the effect of N-feruloylserotonin (N-f-5HT) and methotrexate (MTX) in monotherapy and in combination therapy on disease progression and inflammation in arthritic rats. Adjuvant arthritis was induced by intradermal injection of Mycobacteriumbutyricum in incomplete Freunds adjuvant in Lewis rats. The experiment included healthy animals, arthritic animals without any drug administration, arthritic animals with administration of N-f-5HT in the oral daily dose of 15mg/kg b.w., arthritic animals with administration of MTX in the oral dose of 0.3mg/kg b.w. twice a week and arthritic animals treated with the combination of N-f-5HT and MTX. N-f-5HT in monotherapy reduced only activation of NF-B and did not have any significant

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Fundamental and Clinical Pharmacology

ISSN

0767-3981

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

6

Country of publishing house

FR - FRANCE

Number of pages

11

Pages from-to

616-626

UT code for WoS article

000345305000003

EID of the result in the Scopus database

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