Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00438200" target="_blank" >RIV/61388963:_____/14:00438200 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/14:00438200
Result on the web
<a href="http://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20141111&DB=EPODOC&locale=en_EP&CC=US&NR=8883798B2&KC=B2&ND=4" target="_blank" >http://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20141111&DB=EPODOC&locale=en_EP&CC=US&NR=8883798B2&KC=B2&ND=4</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof
Original language description
The invention provides pyrimidine compounds of general formula (I), which reduce simultaneously the production of nitric oxide (NO) and prostaglandin E2 (PGE2). They have no negative effect on the viability of cells in concentrations decreasing the production of these factors by up to 50%; they are not cytotoxic. Furthermore, a method of preparation of the pyrimidine compounds of general formula (I), carrying 2-formamido group, a pharmaceutical composition comprising the substituted pyrimidine compoundsaccording to the invention, and the use of these compounds for the treatment of inflammatory and cancer diseases are provided.
Czech name
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Czech description
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Classification
Type
P - Patent
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Patent/design ID
US8883798
Publisher
US001 -
Publisher name
United States Patent and Trademark Office (USPTO)
Place of publication
Alexandria
Publication country
US - UNITED STATES
Date of acceptance
Nov 11, 2014
Owner name
Ústav organické chemie a biochemie AV ČR, v. v. i. - Ústav experimentální medicíny AV ČR, v. v. i
Method of use
A - Výsledek využívá pouze poskytovatel
Usage type
A - K využití výsledku jiným subjektem je vždy nutné nabytí licence