Bioassay-guided isolation of the antinociceptive compounds motiol and beta-sitosterol from Scorzonera latifolia root extract
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00438445" target="_blank" >RIV/61388963:_____/14:00438445 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/14:43872709
Result on the web
<a href="http://dx.doi.org/10.1691/ph.2014.3920" target="_blank" >http://dx.doi.org/10.1691/ph.2014.3920</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1691/ph.2014.3920" target="_blank" >10.1691/ph.2014.3920</a>
Alternative languages
Result language
angličtina
Original language name
Bioassay-guided isolation of the antinociceptive compounds motiol and beta-sitosterol from Scorzonera latifolia root extract
Original language description
Scorzonera latifolia (Asteraceae) is a plant widely distributed in Central and East Anatolia. A mastic, named yaki sakizi, is prepared from the latex and roots of S. latifolia and similar species. This latex is used in Turkish folk medicine for its analgesic activity, as anthelmintic and against infertility. The aim of this study was to isolate the compounds responsible for the antinociceptive activity of S. latifolia using bioassay-guided fractionation. The methanolic extract of the S. latifolia rootswas prepared and subjected to chromatographic purification. Isolated active compounds were identified by means of MS and NMR techniques. Writhing and tail-flick tests were used to determine antinociceptive activity. Motiol and beta-sitosterol were isolated as compounds with promising antinociceptive activity. It is suggested that antinociceptive activity of the plant extract is probably caused by the synergic interaction of the isolated compounds.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmazie
ISSN
0031-7144
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
9
Country of publishing house
DE - GERMANY
Number of pages
4
Pages from-to
711-714
UT code for WoS article
000341620200014
EID of the result in the Scopus database
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