Carborane-beta-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00443140" target="_blank" >RIV/61388963:_____/15:00443140 - isvavai.cz</a>

Result on the web

<a href="http://pubs.rsc.org/en/content/articlepdf/2015/tb/c4tb01489h" target="_blank" >http://pubs.rsc.org/en/content/articlepdf/2015/tb/c4tb01489h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c4tb01489h" target="_blank" >10.1039/c4tb01489h</a>

Result language

angličtina

Original language name

Carborane-beta-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

Original language description

Supramolecular chemistry provides an attractive entry to generate dynamic and well-controlled bioactive surfaces. Novel host-guest systems are urgently needed to provide a broader affinity and applicability portfolio. A synthetic strategy to carborane-peptide bioconjugates was therefore developed to provide an entry to monovalent supramolecular functionalization of beta-cyclodextrin coated surfaces. The beta-cyclodextrin carborane-cRGD surfaces are formed efficiently and with high affinity as demonstrated by IR-RAS, WCA, and QCM-D, compare favourable to existing bio-active host-guest surface assemblies, and display an efficient bioactivity, as illustrated by a strong functional effect of the supramolecular system on the cell adhesion and spreading properties. Cells seeded on the supramolecular surface displaying bioactive peptide epitopes exhibited a more elongated morphology, focal adhesions, and stronger cell adhesion compared to control surfaces. This highlights the macroscopic func

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

—

Project

<a href="/en/project/LH11027" target="_blank" >LH11027: Biocompatibilization and Targeting of Nanoparticles for Diagnostic and Therapeutic Applications</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

—

Volume of the periodical

3

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

539-545

UT code for WoS article

000346906500002

EID of the result in the Scopus database

2-s2.0-84919897986